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Pesquisa : ESTRUTURA TERCIARIA DE PROTEINA [Descritor de assunto]
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Id:18467
Autor:Kang, Tae Jin; Lee, Seong-Beom; Chae, Gue-Tae
Título:A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy
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Fonte:s.l; s.n; Oct. 2002. 7 p. graf.
Resumo:Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections, and the mutations in the TLR2 have been shown to confer the susceptibility to infection with mycobacteria. We previously reported the detection of TLR2 Arg677Trp mutation in lepromatous leprosy. Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative agent of leprosy, were investigated. Upon stimulation with MLL, monocytes produced TNF-alpha and Interleukin-12 (IL-12), which play a role in the innate immune response to infection. Anti-TLR2 mAb blocked greater than 50 per cent of the MLL-induced production of IL-12. We also performed the functional study on TLR2 by measurement of IL-12 production in serum and monocytes from leprosy patients with TLR2 mutation (Arg677Trp). The monocytes obtained from patients with the TLR2 mutation, in comparison to the wild-type TLR2, is significantly less responsive to MLL. It was also confirmed that patients with TLR2 mutation showed significantly lower serum levels of IL-12, in comparing with TLR2 wild-type. Our results reveal that innate immune response of monocytes against M. lepraeis mediated by TLR2, and suggest that the mutation in the intracellular domain of TLR2 gene is associated with IL-12 production in lepromatous leprosy. (AU).
Descritores:SEQUÊNCIA DE AMINOACIDOS
SEQUÊNCIA DE BASES
ESTUDOS DE CASOS E CONTROLES
DNA COMPLEMENTAR/genet
IMUNIDADE NATURAL
INTERLEUCINA-12/bios
HANSENIASE VIRCHOWIANA/genet
HANSENIASE VIRCHOWIANA/imunol
GLICOPROTEINAS DE MEMBRANA/quim
GLICOPROTEINAS DE MEMBRANA/genet
MONOCITOS/imunol
MYCOBACTERIUM LEPRAE/imunol
MUTACAO PUNTUAL
POLIMORFISMO (GENETICA)
ESTRUTURA TERCIARIA DE PROTEINA
RECEPTORES DA SUPERFICIE CELULAR/quim
RECEPTORES DA SUPERFICIE CELULAR/genet
FATOR DE NECROSE TUMORAL/bios
Limites:HUMANO
SUPPORT, NON-U.S. GOV'T
HUMANO
IN VITRO
Meio Eletrônico: - .
Localização:BR191.1; 09004/s


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Id:15043
Autor:Ulrichs, T; Porcelli, S. A
Título:CD1 proteins: targets of T cell recognition in innate and adaptive immunity
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Fonte:s.l; s.n; 2000. 17 p. ilus, tab.
Descritores:FORMAÇAO DE ANTICORPOS
APRESENTAÇAO DO ANTIGENO
ANTIGENOS DE BACTÉRIAS
ANTIGENOS DE BACTÉRIAS
ANTIGENOS CD1
ANTIGENOS CD1
ANTIGENOS CD1
ANTIGENOS CD1
EVOLUÇAO MOLECULAR
GLICOLIPIDIOS
GLICOLIPIDIOS
IMUNIDADE NATURAL
CÉLULAS KILLER NATURAIS
HANSENIASE
LIPIDIOS
LIPIDIOS
COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE
MAMIFEROS
MAMIFEROS
CAMUNDONGOS
MODELOS MOLECULARES
MYCOBACTERIUM
MYCOBACTERIUM
CONFORMAÇAO PROTÉICA
ESTRUTURA TERCIARIA DE PROTEINA
RATOS
RECEPTORES PARA ANTIGENOS DE CÉLULAS T GAMA-DELTA
ESPECIFICIDADE DE ESPÉCIES
SUB-POPULAÇOES DE LINFOCITOS T
TUBERCULOSE
Isoformas de Proteínas/CH/CL/GE/IM
Limites:ANIMAL
Localização:BR191.1; 07486/s



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